题目：Chiral Lewis Bases for Asymmetric Organocatalysis

主讲人：Prof. Mario Waser, Johannes Kepler University Linz

时间：2024年7月25日 16:00-17:00

地点：霞光楼220会议室

邀请人：叶俊涛 副教授

个人简介

Mario Waser obtained his PhD in organic chemistry under the supervision of Prof. Heinz Falk at the Johannes Kepler University Linz (JKU Linz) in 2005. Shortly after, he moved to Max-Planck Institute in Germany and joined the group of Prof. Alois Fürstner as a Postdoctoral Fellow. In 2009, he started his independent career at the JKU Linz as an assistant professor and was promoted to full professor in 2020. He was appointed as head of the institute of organic chemistry in 2021. His research interests include the design of chiral ammonium salt catalysts and their use in method development, chiral Lewis base catalysis, and synthesis of chiral non-natural amino acids. He has received many awards, including Erwin Schrödinger Fellowship, JSP fellowship, and Kardinal Innitzer young researcher award talents.

报告摘要

Chiral Lewis bases (LBs) are versatile nucleophilic organocatalysts that allow for numerous highly enantioselective transformations. Over the last years our group had a strong interest in the utilization of chiral LBs (i.e. isothioureas, phosphines, amines) for the activation and control of simple carboxylic acid derivatives (via in situ C1 ammonium enolate formation) and allenoates (via in situ betaine formation) for numerous applications. In this presentation I will give an overview of our most recent results, presenting past and ongoing investigations focusing on the development and mechanistic understanding of new cyclization reactions as well as new a-functionalization chemistry.