2007.09 - 2013.07 北京大学，前沿交叉学科研究院，博士

2002.09 - 2006.07 南昌大学，生命科学学院，学士

2018.07 -2023.06 耶鲁大学，分子生物物理学与生物化学系，研究科学家

2014.07 -2018.07 耶鲁大学，细胞生物学系，博士后

核酸与蛋白质纳米装置设计、组装与应用；

DNA纳米反应器设计与应用；

DNA纳米通道设计与应用

国家海外高层次引进人才计划，2024-2026，主持

1.     Q. Shen, Q. Feng, Q. Xiong, C. Wu, Y. Yuan, T. Tian, S. Yuan, J. Temple, C. Aiken, A.N. Engelman, C.P. Lusk, C. Lin, and Y. Xiong, "Modeling HIV-1 nuclear entry with nucleoporin-gated DNA-origami channels",  Nature Structural & Molecular Biology, 2023, 30, 425-435.

2.     P. Zhan, A. Peil, Q. Jiang, D. Wang, S. Mousavi, Q. Xiong, Q. Shen, Y. Shang, B. Ding, C. Lin, Y. Ke, and N. Liu. "Recent Advances in DNA Origami-Engineered Nanomaterials and Applications", Chemical Reviews, 2023, 123, 3976-4050

3.     Q. Shen, S. Kumari, C. Xu, S. Jang, J. Shi, R.C. Burdick, L. Levintov, Q. Xiong, C. Wu, S.C. Devarkar, T. Tian, T.N. Therese, Y. Hu, S. Yuan, J. Temple, Q. Feng, P. Lusk, C. Aiken, A.N. Engelman, J. Perilla, V.K. Pathak, C. Lin, and Y. Xiong, "The capsid lattice engages a bipartite NUP153 motif to mediate nuclear entry of HIV-1 cores", Proc Natl Acad Sci USA, 2023, 120, e2202815120.

4.     W. Luo, V. Demidov, Q. Shen, H. Girão, M. Chakraborty, A. Maiorov, F. Ataullakhanov, C. Lin, H. Maiato, E. Grishchuk. "CLASP2 recognizes tubulins exposed at the microtubule plus-end in a nucleotide-state sensitive manner", Science Advances, 2023, 9, eabq5404.

5.     Q. Shen^#, Q. Xiong^#, K. Zhou, Q. Feng, L. Liu, T. Tian, C. Wu, Y. Xiong, T.J. Melia, C.P. Lusk, and C. Lin, "Functionalized DNA-Origami-Protein Nanopores Generate Large Transmembrane Channels with Programmable Size-Selectivity", J Am Chem Soc, 2023, 145, 1292–1300.

6.     Q. Shen, C. Wu, C. Freniere, T. N. Tripler, Y. Xiong. "Nuclear Import of HIV-1", Viruses, 2021, 13, 2242

7.     Q. Shen, T. Tian, Q. Xiong, P.D.E. Fisher, Y. Xiong, T.J. Melia, C.P. Lusk, and C. Lin, "DNA-Origami NanoTrap for Studying the Selective Barriers Formed by Phenylalanine-Glycine-Rich Nucleoporins", J Am Chem Soc, 2021, 143, 12294-12303.

8.     Q. Shen and C. Lin. "RNA returns to the fold", Nature Chemistry, 2020, 12, 221-222.

9.     Y. Hu, K. Knecht, Q. Shen, Y. Xiong, "Multifaceted HIV-1 Vif interactions with Human E3 Ubiquitin Ligase and APOBEC3s". FEBS J., 2020, 288, 3407-3417.

10.  S. Yuan, L Peng, J. J. Park, Y. Hu, S. C. Devarkar, M. B. Dong, Q. Shen, S. Wu, S. Chen, I. B. Lomakin, and Y. Xiong. "Nonstructural Protein 1 of SARS-CoV-2 Is a Potent Pathogenicity Factor Redirecting Host Protein Synthesis Machinery toward Viral RNA",  Molecular Cell, 2020, 80, 1-12.

11.  Q. Xiong, C. Xie, Z. Zhang, L. Liu, J. Powell, Q. Shen, and C. Lin, "DNA Origami Post-Processing by CRISPR-Cas12a", Angew Chem Int. Edit, 2020, 59, 3956-3960.

12.  J. Temple^#, T.N. Tripler^#, Q. Shen^#, Y. Xiong. "A snapshot of HIV-1 capsid–host interactions", Curr Res Struct Biol, 2020, 2, 222-228.

13.  Q. Shen, M.W. Grome, Y. Yang, and C. Lin. "Engineering Lipid Membranes with Programmable DNA Nanostructures", Adv Biosyst, 2020, 4, 1900215.

14.  P. Fisher^#, Q. Shen^#, B. Akpinar, L. Davis, K. Chung, D. Baddeley, A. Šarić, T. Melia, B. Hoogenboom, C. Lin, and P. Lusk. "A Programmable DNA Origami Platform for Organizing Intrinsically Disordered Nucleoporins within Nanopore Confinement", ACS Nano, 2018, 2, 1508-1518. 

15.  Q. Shen^#, C. Zhang^#, J. Cao, Y. Liu, Y. Liang, M. Zhao, and L. Lai. "De novo design of helical peptides to inhibit TNFα by disrupting its trimer formation", MedChemComm, 2016, 7, 725-729.

16.  Q. Shen^#, J. Chen^#, Q. Wang, X. Deng, and L. Lai. "Discovery of highly potent TNFα inhibitors using virtual screening", Eur J Med Chem, 2014, 65, 119-126.

17.  G. Stanley, B. Akpinar, Q. Shen, PDE. Fisher, C.P. Lusk, C. Lin, and B. Hoogenboom, "Quantification of Biomolecular Dynamics Inside Real and Synthetic Nuclear Pore Complexes Using Time-Resolved Atomic Force Microscopy", ACS Nano, 2019, 13, 7949-7956.

18.  C. Zhang^#, Q. Shen^#, B. Tang, and L. Lai. "Computational design of helical peptides targeting TNFα", Angew Chem Int Edit, 2013, 52, 11059-11062.

2023年，罗伯特德克斯分子编程奖，国际纳米科学、计算和工程学会

2023年，国家高层次青年人才计划

长期招收来自生物、化学、医学、生物医学工程、计算机等跨学科领域的本科生、研究生和博士后，欢迎有志于从事高水平创新研究的同学加入！